Also known as Pirglutargine and Arginine Pidolate.
Arginine Pyroglutamate is the L-Arginine salt of Pyroglutamic Acid, and is comprised of the amino acids L-Arginine and Pyroglutamate. Arginine Pyroglutamate is a delivery form of Pyroglutamate, which is formed in the body by the cyclisation of the amino acid Glutamic Acid, and is found naturally in the brain, as well as various other plant and animal products.
Arginine Pyroglutamate is a water-soluble substance. Since its action is unclear, its mechanism of action is speculative, however, it is structurally related to the drug Piracetam, and so information can be gathered from the known actions of this drug. Piracetam belongs to a class of drugs known as nootropics, a Greek term meaning ‘acting on the mind’. Piracetam and related nootropics facilitate learning and memory in animals, although human studies give mixed results, with the exception of dyslexia. The effects of piracetam are thought to be mediated through effects on membrane fluidity in the brain. The primary claim made is that Arginine Pyroglutamate relates to cognitive enhancement - it is thought by some that this substance can help to overcome memory defects induced by alcohol abuse, and those due to some forms of dementia. In Italy, it is sometimes used to treat alcoholism, senility and mental retardation.
How significant the role is for Arginine Pyroglutamate to enhance cognition is not fully established, although some animal studies show that the substance has positive effects in cortical and cholinergic mechanisms and that it has cognition-enhancing properties. In one double-blind study of aged human subjects, verbal memory was also improved in those taking Arginine Pyroglutamate compared with controls that received a placebo.